Association between Ankylosing Spondylitis and the miR-146a Polymorphisms a Samples of Iraqi Patients

Abstract

MicroRNAs (miRNAs) are small noncoding sequence  that regulate the expression of multiple target genes at the post-transcriptional level, efficiently regulating fundamental cellular processes such as proliferation, apoptosis, and development. Ankylosing spondylitis (AS) is a chronic inflammatory rheumatic illness of mysterious etiology with a strong genetic susceptibility. Important development is being made in our considerate of the pathogenetic tools involved in this illness, and the recent genome-wide association study (GWAS) consequences have related at least 60 loci to As, The present study explored the association between ankylosing spondylitis (AS) and two single nucleotide polymorphisms (SNPs), miR-146a rs2910164G>C, in Iraq population. The genetic analysis of the Single Nucleotide Polymorphisms, for miR-146a gene by using PCR-SSCP technique that there was significant difference in genotype polymorphisms between patients and control . Also this research found relationship  between miR-146a and Osteoprotegerin ,interleukin 23serum level in AS patients .