Evaluation of Iraqi patients with psoriatic diseases and their systemic impact on disease activity. 1Randa R. Ghamyes, 2 AbdulKareem A. Alkaza

Abstract

Background Psoriasis (PsO) and psoriatic arthritis (PsA) are immune-mediated inflammatory disorders that may share immunological and genetic features. Due to their inflammatory nature, psoriatic diseases significantly affect kidney and liver health. Aim The study aimed to evaluate the kidney and liver characteristics of PsO and PsA patients. Methods This case-control study includes 137 patients (70 PsO and 67 PsA) and 120 healthy controls. WBCs were counted and ESR was measured using an auto-hematology analyzer (BC-700 Series, Mindray, China), while serum concentrations of ALT, AST, SCr, and BUN were tested using Cobas c311 analyzer (Roche, Germany). Results The present study findings displayed a significant difference in only two markers: ESR (22.6 ± 16.1 vs. 14.2 ± 11.6; p = 0.001) and SCr (2.74 ± 1.24 vs. 0.76 ± 0.22; p = 0.009) levels were significantly higher in PsA patients than in PsO patients. Results also showed a positive association between ESR and disease activity in psoriatic patients. Conclusion Creatinine levels were higher in PsA than in PsO patients, and ESR was elevated in both groups, influencing disease activity