Association of HLA-DRB1, DQB1 with Thyroid Disorders in Sample of Iraqi Patients

Abstract

This study was carried out to evaluate some immunogenetic parameters of some Iraqi patients with thyroid disorders. Forty patients suffered from thyroid disorders who were admitted to the Department of Radiation, Nuclear Medicine Hospital in Baghdad and 30 healthy control during the period from June to October- 2011. The age of patients and healthy individuals ranged between 13-71 years.  The HLA-class II typing was conducted for three groups the first group consisted of patients  with hyperthyroidism, hypothyroidism and thyroid non toxic goiter patients, the second group consisted of thyroid cancer patients and the third group consist of healthy individuals. By using molecular methods polymerase chain reaction- sequence specific oligonucleotide (PCR- SSO)  for HLA-Typing , the results showed that high frequencies of  HLA DRB1*13and HLA-DRB1*10 (P<0.01 and P<0.05 , respectively) in thyroid cancer patients when compared with control group. Whereas the frequency of HLA-DQB1*06 significantly (P<0.05)  increased in healthy control group compared to thyroid disorders patient groups. The results suggested that the immunogenetic markers such as HLA-DQB1*06 allele may have a protective effects against the development of thyroid disorders.