Prevalence of Matrix metalloproteinase-9 in Breast Cancer As a Marker of Prognosis

Abstract

Matrix metalloproteinase-9 (MMP-9) is regarded as important for degradation of the basement  membrane and extracellular  matrix during cancer invasion and other tissue-remodeling events. the aim of this study is to investigate and compare the expression of MMP-9 in human breast adenocarcinoma with fibroadenoma. In this study we evaluate the prognostic value of MMP-9, by in situ hybridization staining in a series of 30 breast cancer tissues. Both mean percentage of MMP-9   MRNA and scoring of it,s expression in normal and cancer, showing an increased expression of MMP-9 was significantly high in tumor compared with control samples, with extensive score among breast cancer tissues. This study shows that MMP-9 expression in breast cancer is associated with better prognosis.