Association between GSTM1, GSTT1 Genes Variants and Some Physiological Parameters in Infertility Patients

Abstract

: Several studies refer to higher levels of oxidative stress are associated with infertility. The purpose of this study to know the genotype frequency of GSTM1 and GSTT1 genes in infertility patients and assest the relationship between the genes and some physiological parameters in infertility patients. Genotype (GSTM1 and GSTT1) genes were determined by multiplex polymerase chain reaction (PCR). The result showed a significant increase in serum malondialdehyde (MDA), in unexplained Infertile (oligozoospermia and asthenozoospermia) groups compared fertile (Control) groups,. While,the result showed a significant decrease in serum glutathione (GSH) , in unexplained Infertile (oligozoospermia and asthenozoospermia) groups compared fertile(Control) groups, the percentage of genetic deletion in oligozoospermia samples  as follows : The deletion of GSTM1 ,GSTT1  and null genotype (deletion of GSTM1 and GSTT1) are most common in infertility patients (oligozoospermia , asthenozoospermia) when compared to control group..  It could be concluded there use of measuring GSH and MDA activity to assess infertility patients as the first line deface. These parameters of the marker in infertility patients.