Role of miRNA-21-5p Gene Expression as a Tumor Marker and the Progression of Clinic-Pathological Characters in Breast Cancer Iraqi Female Patients

Abstract

Breast cancer is a malignancy of the breast tissues that arise from uncontrolled proliferation of breast ductal and lobular epithelial cells. It’s the most prevalent malignancy among the Iraqi women. The aims of study are analyzing the expression of serum (miR-21-5p) as a molecular tumor marker and main clinic pathological characters for patients and healthy control groups. Determination of microRNA gene expression by (qRT-PCR) for both BC patients’ healthy control and statistical analysis of their demographic characteristics. The results show that high significant up regulation of serum miRNA-21 expression in BC patients (5.27) times than control group and the main clinic-pathological data show high percentage of (IDC) histopathology type, (T2) staging, the hormone receptors ER+, PR+, high metastasis LN+ and the molecular subtypes Luminal-A than other characters. In conclusions the high miRNA-21 expression levels make it act as noninvasive diagnostic tumor marker and show the aggressive phenotype progression BC diseases’ characters.