Evaluation of some Biochemical Parameters in Iraqi Patients with Hyperthyroidism

Abstract

Hyperthyroidism is autoimmune disease that is considered a thyroid gland problem. A clinical condition known as hyperthyroidism is defined by the thyroid gland producing and secreting an excessive amount of thyroid hormones. Lipid profile play an essential role in the progression and development of hyperthyroidism. The aim of this study is to evaluate the level of some biochemical parameters in Iraqi patients with hyperthyroidism. Sixty hyperthyroid patients and  30 healthy individuals with age range from (30-65) years were enrolled in this study during their attendance at the National Center for Diabetes Treatment and Research in Baghdad from the period between December 2021 to April 2022 .Blood samples were collected to evaluate the level of thyroid hormone like triiodothyronin (T3), thyroxin (T4) and thyroid stimulating hormone (TSH) using ELISA technique, and total cholesterol (TC), triglycerides (TG), high- density lipoprotein cholesterol (HDL-C) were measured spectrophotometrically by using different type of kits. The results showed highly significant (p≤0.01) increase in the level of T3, T4 in the patients with hyperthyroidism in comparison with the control group, While, TSH level showed highly significant (p≤0.01) decrease in the patients with hyperthyroidism as compared with control group. The level of TC, HDL-C and LDL-C showed a highly significant (p≤0.01) decrease in the patients with hyperthyroidism in comparison with the control group, While, the level of TG and VLDL-C showed a highly significant (p≤0.01) increase in the patients with hyperthyroidism in comparison with the control group. It can be concluded that the lipid profile play a major role in the pathogenicity of hyperthyroidism.