Study of some Hematological and Physiological Parameters and Electrolytes in Cardiomyopathy Iraqi Patients

Abstract

Cardiomyopathy (CM) is a condition that affects the heart muscle and can lead to heart failure. It can be dilated, hypertrophic, or restricted. This study was aimed to investigate the level of physiological and biochemical parameters in CM. Sixty patients with age (40-70), and thirty healthy controls with the same age range, were involved in this study during their0attendance to Iraqi Center for Heart Diseases, Ghazy Al-Hariri Hospital for Surgical Specialties in the Medical City in Baghdad. The patients were diagnosed by an expert cardiologist. The study was conducted from November 2021 to April 2022, and approved by ethical committees: Ref.:0CSEC/0121/0074 on October 20, 2021of Department of Biology, College of Science, University of0Baghdad. Blood samples and data were collected to evaluate the level of complete blood counts (CBC), some biochemical parameters like Troponin T, creatine kinase - MB (CK-MB), C-reactive protein (CRP), Lactate dehydrogenase (LDH), and blood electrolytes like (Magnesium Mg++, Sodium Na⁺, Potassium K⁺, and Calcium Ca⁺⁺)   for the patients and control. Results appeared that mean total WBC count, Lymphocyte, and Monocytes percentages were significantly (P≤0.01) increased in CM patients as compared with control, while there was a highly significant (P≤0.01) decrease in RBC, Hb, and HCT in CM patients as compared with control, the levels of CK-MB, LDH, and CRP in CM patients was a significant increase as compared with the control group. Referring to electrolytes results, the levels showed that there was a significant (P≤0.01) increase in the levels of both Mg+2 and k+ in patients with CM as compared with the control group, While the level of Na+ was decreased in CM patients. It can be concluded from the current results that the wide range of biochemical abnormalities play a major role in the pathogenicity of CM patients.