Detection of Hematological and Biochemical Manifestations Associated with Women infected by Systemic Lupus Erythematosus

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease in which the immune system attacks its own tissues. This study was aimed to investigate the hematological and chemical manifestations of SLE Iraqi women sample by focused on tests which related with SLE disease, as hematological tests that included: complete blood count (CBC) and erythrocyte sedimentation rate (ESR), also, chemical tests to evaluate renal function (blood urea and serum creatinine), and the ratio of protein calculated by urine strip only. The results (mean ± SE) of patients vs. control showed that ESR level was 40.08 vs. 10.96 mm/hour, Blood urea was 33.41 ±1.40 vs. 27.11 ±0.82 mg/dl with highly significant difference at P≤0.01, Creatinine was 0.758 ±0.04 vs. 0.651 ±0.02 mg/dl, with significant difference at P≤0.05 and protein urea percentages was 50 (83.33%) vs. 3(5.00%) with highly significant difference at P≤0.01. while hemoglobin was 11.37 ±0.20 vs. 12.90 ±0.08 g/dl, and platelets was 230.75 ±13.86 vs. 285.83 ±10.06 *10^3 / µl with highly significant difference at P≤0.01, white blood cells were 7.28 ±0.46 vs. 6.29 ±0.13cell X 10^3 / µl, with significant difference at P≤0.05. It concluded that it is evident that hematological testing and SLE disease are known to be related. And may interact with a variety of biomarker results and be used to forecast disease severity, which could be beneficial for SLE patients by expanding their options for diagnosis and treatment.