Demographic and Biochemical Study of Beta Thalassemia Major Associated with Liver and Pancreas Disorders in Adult Sample of Patients from Baghdad province

1*Hawraa  A.  Luaibi , 1Bushra J. Mohammed

1*Hawraa A. Luaibi , 1Bushra J. Mohammed

Abstract

β-thalassemia is an inherited autosomal recessive blood disorder results from decreased or missing synthesis of beta globin chains in hemoglobin. This study was aimed to examine the relationship between liver and pancreas disorders of beta thalassemia major with demographic and biochemical aspects, in adult Iraqi patients. Blood samples were collected from 40 patients suffered from beta thalassemia with pancreas disorder as group A, along with 40 patients suffered from thalassemia with liver disorder as group B, and 40 patients suffered from thalassemia without pancreas or liver disorders as group C, from Ibn Al-Baladi Hospital, Baghdad, and 40 samples from age and gender-matched apparently healthy individuals as a negative control (Group D), all subjects with age more than 18 years. Ferritin serum level was determined by using automated immunocheiluminometric analyzer. ALT level was estimated through Atellica™ CH Analyzer, and amylase was evaluated via ARCHITECT c4000 device. The results revealed that the highest number of thalassemia patients located at the age group (18-28) years with high significant difference (P≤0.01), which was 91 (75.83%), and higher incidence was for male patients 72 (60%) with significant difference (P< 0.05). Also results showed elevation of ferritin level in all patient groups when compared with control, and the highest value appeared in liver disorder patients (4014.9 ng/ml) with high significant difference (P<0.01). The results revealed that ALT level was significantly higher (76.430 U/l in liver disorder patients, as well as results showed that the level of amylase was lower in all patient groups as compared to the control group (84.150 U/l) with high significant difference (P<0.01). This study concluded that there was relationship between liver and pancreas disorders of beta thalassemia major with ferritin, ALT and amylase in adult Iraqi patients.