Investigation of IL-4 (rs2243250) Gene Polymorphism in Sample of Iraqi Allergic Patients

Abstract

Allergy is the reaction by your immune-system. Substances that cause reactions include food and pollen. The study was aimed to reveal circulating T-lymphocyte-subsets and related cytokines during asthmatic-attacks is still unclear. This study included 89 subjects total; 31 controls, 23 Allergy Food and 35 Allergic Rhinitis individuals. The aim of this study is to estimate the Total IgE levels in allergic patients and healthy control subjects. Also, investigates about single nucleotide polymorphisms (rs2243250) of IL-4 genes in allergic diseases such as, allergic rhinitis and allergic food. Patients' serum IgE levels were noticeably greater than those of the controls (AF: 234.4 ± 35.8, AR: 253.4± 29.1, control: 48.0 ± 5.7 IU/ml, P<0.001).  The CC genotype in the IL-4 gene was not related with AR patients. Additionally, the polymorphism (rs2243250 = C-590T) in the IL-4 gene had no correlation with AR in the sample being examined due to the sample size of the subject was small. It was concluded the sample being examined and IgE is a unique immunoglobulin that plays a central role in the pathophysiology of allergic disorders.