Association of Genetic Polymorphism rs20541 at IL-13 gene with Susceptibility to Allergic Asthma

Abstract

An imbalance exists between the forces preserving the patency of the airway and those attempting to constrict or close it in asthma, a lung deficiency illness. The purpose of this study is to determine if SNP (rs20541) in the IL-13 gene is linked to asthma in the sample of Iraqi population as well as to assess the relationship between total IgE serum level and eosinophils count with IL-13 SNP (rs20541). At the central allergy center in Baghdad, a cases-controls study was carried out from September 2019 to November of 2019. Asthma patients with ages of 10 to 65year, of both genders, were enrolled in this study and matched in age and gender with the control group of healthy individuals without a history of chronic disease. There were 60 subjects total, including 20 controls and 40 asthmatic sufferers. The average age of asthma patients was 34.9±15 years, compared to 37±12.4 years for the control group. According to the study, the difference in asthmatic mean age from the control group is not statistically significant (p=0.3). The rs20541 (AA+AG) genotype SNP was found to have a significant genetic connection in this study with IL-13 and the protective factor (GG) in the Iraqi population (AA+AG: OR=7.36, 95% CI= 1.50 - 36.04, p=0.006, GG: OR= 0.14, 95% CI= 0.03-0.64, p=0.008).  It was concluded that A allele has a substantial relationship to the severity of asthma and is associated with higher levels of the biomarkers (Eosinophil count and Total IgE). In individuals with allergic asthma, this polymorphism (rs 20541) significantly linked with higher Eosinophil count and Total IgE levels.