Potential Protective Effects of Citrus Peel Extract on Biochemical and Molecular Changes Induced by Deltamethrin Insecticides

  • 1Hind B. Mohammed Aldik, 1 1Adel H. Talib

Abstract

Concerns have been raised about the safety of using the pyrethroid pesticide deltamethrin due to its harmful effects on animals. The purpose of this research was to see whether citrus peel extract might prevent the toxicity caused by deltamethrin in rats. Seven groups (n=6) of adult male Wistar rats were used, each receiving either a placebo, deltamethrin (6 mg/kg), or a combination of deltamethrin with either mandarin or lemon extracts. Ten weeks into therapy, researchers looked at how things were doing from a biochemical, antioxidant, hormonal, and histopathological standpoint. Hormonal disruption was indicated by lower levels of estrogen, progesterone, and follicle stimulating hormone (FSH), as well as substantially raised levels of liver enzymes and altered kidney function indicators due to deltamethrin exposure. These deltamethrin-induced changes were attenuated when subjected to a co-treatment with citrus peel extracts, especially a mixture of mandarin and lemon. The combination of mandarin and lemon improved antioxidant status, normalized indices of kidney and liver function, and restored hormonal balance. Citrus peel, which is loaded in antioxidant phytochemicals, may be responsible for its beneficial properties. It was concluded that citrus peel extract with your deltamethrin exposure may help reduce the risk of adverse effects. Its therapeutic use against pyrethroid toxicity would benefit from further research into the bioactive chemicals and the processes through which they work.

Published
2025-01-07