Impact of IL-22 SNP (rs761162880), Serum Ferritin, D-Dimer and C-Reactive Protein in Sever COVID-19 Patients

Abstract

People with COVID-19 infection experience a range of problems, each with differing degrees of severity. Because of this, assessing its analytical values is essential to anticipating and minimizing the dangers and difficulties associated with this condition. This study was conducted to determine whether the COVID-19 severity is correlated with the polymorphisms of SNP(rs761162880), in the IL-22 gene. Investigations the role of serum ferritin, D-dimer and C-reactive protein in COVID-19 severity. For the detection of SARS-COV-2, RT-PCR was used. The samples were subjected to D-dimer, ferritin, and CRP tests.  Polymerase Chain Reaction (PCR) and DNA sequencing was used for genotyping. The findings showed that there was a significant increase in ferritin, D-dimer and CRP (p value <0.01). In order to forecast and avoid potential COVID-19 consequences.  It was concluded the crucial to analyse the biochemical parameters of individuals infected with the virus in order to evaluate the severity and course of the illness. COVID-19 severity is not correlated with the polymorphisms of SNP(rs761162880).