The Effect of Vitamin D3 on Human Papilloma Virus Patients

Abstract

The most common sexually transmitted disease in postmenopausal women is human papillomavirus genital infection. Vitamin D deficiency has been associated to HPV infection persistence and the development of cervical pre-invasive lesions. The current study's aims were to detect HPV virus using RT-PCR and show a link between HPV infection and its influence on vitamin D3 levels, BMI, and age groups who are more infected than others. From November 2022 to February 2023, 100 women were recruited from Al-Elwiya Maternity Teaching Hospitals and the Central Health Laboratory in Baghdad. The samples were separated into two groups: those with various gynecologic disorders (patients) and those with normal Pap smear results (control). Cytology, hematology, and hormonal testing were performed on the samples. A study of 50 women with cervical anomalies discovered that 80% were negative for HPV testing, whereas 20% were positive. Also there were nine genotypes discovered among HPV infected patients. Regarding D3, the data suggest that (70%) about 7 of the infected individuals had levels equal to or lower than 30ng/mL. and around 30% (3) of the total ten infected patients were greater than 30 ng/ml. The age distribution of the infected patients was 40% under 30, 60% 30-50, and 30% greater than 30ng/mL. BMI measurements revealed that 80% of patients were overweight, whereas the remaining 20% were obese. The total HPV infection incidence changes modestly between age groups before and after menopause, with the highest rate occurring between the ages of 30 and 50. Vitamin D concentrations Low 25(OH) D levels in blood have been associated to impaired innate immune response and increased vulnerability to HPV infection. Obesity causes a hormonal tangle, reducing immunity and increasing the chance of HPV infection.