Study the rs2069154005 and rs6928 MAPK1 Gene Polymorphism in a Sample of Iraqi Patients with Chronic Myeloid Leukemia

Abstract

Chronic myeloid leukemia (CML), is characterized by a startling excess of immature and mature granulocytes. In 90–95% of cases of CML, the Philadelphia (Ph) chromosome is present results from reciprocal translocation of chromosomes 9 and 22. The aim of study was the association between the polymorphisms of the MAPK1 gene rs2069154005 and rs6928 in susceptibility to develop CML.  This study consists of three groups, first group includes fifty newly diagnosed CML patients (females 22, males 28), second group consisted of fifty CML patients treated with tyrosine kinase inhibitor (TKI) (female 25, male 25). Third group included another fifty apparently healthy volunteers (female 20, male 30). The patients were admitted from the National Center of Hematology/ Mustansiriyah University. All patients diagnosed according to complete blood count (CBC), a bone marrow examination, and a BCR-ABL gene test. The result suggests that heterozygous genotype GA of rs2069154005 shows significant differences P≤ 0.05 it was (18%) in chronic CML patient while (4%) in control with OR= (5.1), Homozygous mutant AA genotype of rs2069154005 was 45% in CML patients (Newly diagnosed) and 4% in Control and OR= 345. Homozygous mutant AA genotype frequency of rs6928 was 38% in CML patients (chronic phase) and 0% in Control and shows significant differences with P ≤ 0.05 and OR= 12. AA genotypes are associated with increase the risk of having the disease polymorphisms were related with a risk for CML.