Evaluation the Role of IL-6 as Immunological Markers in Corona Virus-19 Infection in Sample of Iraqi Patients

Abstract

Background: Interleukin 6 (IL-6), promptly and transiently produced in response to infections and tissue injuries, contributes to host defense through the stimulation of acute phase responses, hematopoiesis, and immune reactions. Although its expression is strictly controlled by transcriptional and posttranscriptional mechanisms, dysregulated continual synthesis of IL-6 plays a pathological effect on chronic inflammation and autoimmunity. Objectives Due to the impact of IL-6 as immunological markers in (COVID-19) infection which could be used as a promising diagnostic factors for COVID-19 infections, and evaluation their association with infection progression. Materials and Methods. In this study, 40 patients suffered from coronavirus (Patient group). The blood sample was collected from the patients, who attended Al-Zafaraniyah General Hospital, Fatima-Alzahra Hospital and Al-Yarmook Teaching Hospital in Baghdad City. Nasopharyngeal and oropharyngeal swabs for each patients were taken at the same time then add immediately into viral transport media (VTM) .The Interleukin-6 antibodies in serum of coronavirus Patients were detected by an enzyme linked immune sorbent assay (ELISA) method . Conclusion This repot exhibit remarkable association between patients suffered Covid-19 Infection as Immunological Markers patients.The results showed that Interleukin-6 antibodies in serum of Covid-19 was highly associated with incidence of Covid-19 results of the this study explain that the highest Interleukin-6 antibodies concentrations were higer in 40 Covid-19 patients.