Evaluation of IL-6 and IL-30 Serum level in Addition To Some Biochemical Markers in Iraqi Patients with Chronic Renal Failure

Abstract

Chronic kidney disease CKD is defined as the presence of structural or functional abnormalities of the kidneys for more than three months, with health implications. According to the Kidney Disease: Improving Global Outcomes (KDIGO) guidelines, CKD should be classified according to its cause and category of glomerular filtration rate  (GFR) and albuminuria, which are factors that enable the identification of the risk of adverse outcomes, such as progressive CKD,  end-stage renal disease, acute kidney injury, all-cause mortality and cardiovascular mortality. We aimed to evaluated (IL-6 and IL-30) in Iraqi patients with chronic renal failure and assess some biochemical parameters include (urea, creatinine, protein,albumin, calcium and vitamin D).This study included 88 cases and classified as 44 patients with chronic renal failure, these patients with age range (18 to 65) years who were admitted to the AL-Kindi Dialysis Center during the period from December 2024 to March 2025 Regarding biochemical parameters, it was observed that serum urea (S.urea), serum creatinine (S.creatinine) ,serum potassium (S. K) were increased in chronic renal cases and decrease in Serum calcium (S. Ca,),Serum sodium (S. Na ) and serum vitamin D (S. vit D) in comparison with healthy control group.  **The results showed that male patients constituted 58.1% while the controls were 41.9% out of a total of 43 individuals assigned to the patients’ group. The mean age of the males was 51.16±13.6 and 51.44±11.0 for the patients and the controls, respectively. Moreover, out of a total of 53 females, there was 43.3% patients and 56.6% controls; their mean age was 49.13±12.7 and 42.47±14.0. An Independent-Samples Mann-Whitney U Test was applied to compare the medians serum levels of IL-6 and IL-30 in patients and controls. also  results show highly statistically significant difference (p=0.005) between patients and controls when IL-6 was considered while no difference obtained when IL-30 was taken into consideration.Highly significant elevated of pro-inflammatory cytokines which include IL-6 in chronic renal diseases indicated these cytokines participate in the pathophysiology of reduced renal function and the role of these cytokines as principle mediators of inflammatory reaction in renal damage and these cytokines could be potential therapeutic targets.