Evaluate the Potential Role of MPO, MCP-1, and Hcy levels in the Pathogenicity of Atherosclerosis

Abstract

Atherosclerosis (AS) is a chronic inflammatory disorder causing cardiovascular illnesses, Responsible for rising death rates worldwide. This study aimed to investigates the diagnostic potential of Hcy, MCP-1, and MPO biomarkers. In this study, 90 participants were enrolled, aged 20 to 75, including 60 AS patients divided into two groups: 30 pre-catheterization (Pre-Cath) patients and 30 post-catheterizations (Post-Cath) patients, along with 30 healthy controls. Results revealed significantly elevated levels of Hcy, MCP-1, and MPO in AS patients compared to controls. Higher WHR was significantly correlated with increased levels of Hcy, reinforcing the association between central obesity and vascular inflammation. Notably, MCP-1 and MPO levels were higher in patients with a WHR > 0.9, especially in a group Pre-Cath patients, emphasizing its role in endothelial dysfunction in obese   individuals. Correlation analysis demonstrated that there were many correlations between the parameters, such as association between Hcy and MPO, highlighting their role in vascular inflammation. Higher MCP-1 levels were observed in patients (≤50), particularly in the Post-Cath patients group. In contrast, MPO levels were markedly higher in patients (>50), particularly in Post-Cath cases, highlighting its relevance linking aging to sustained inflammation. These biomarkers play important roles in the diagnosis, onset, and progression of AS, so they can be used to help develop early diagnostic and therapeutic approaches to prevent disease progression.