Interleukin (IL) 17 expression in Iraqi bladder carcinoma Patients

Abstract

Interleukin (IL- 17) is pro inflammatory cytokines produced by CD4+ T-helper17 (Th17)cell  .It has  a vital  effect on cells of the immune system playing crucial  roles in pathogenesis of immune-mediated diseases, like-cancers. The current study was designed to detect the protein expression of IL-17 in Iraqi bladder carcinoma patients, and its correlation with clinical grades. Tissue samples were collected from 45 patients with bladder carcinoma. The immunoexpression of IL-17 was detected by using IL-17 monoclonal   antibody. The results of Immunohistochemical (IHC) studying showed that tissues with positive (IL-17) expression were low in bladder cancer patients practically in low grades with significant difference, it is concluded that IL-17 expression can be used as indicators for procession in bladder cancer.