Estimation of Serum Level and rs17855750 A/C Genetic Polymorphism of Interleukin-27 in Hashimoto Thyroiditis Patients

Abstract

Hashimoto’s thyroiditis (HT) is a prevalent autoimmune disorder characterized by lymphocytic infiltration and thyroid destruction, leading to hypothyroidism. Cytokines, particularly IL-27, are essential mediators that balance self-tolerance and the initiation of autoimmune responses. Aim.  The objective of this study is to evaluate serum IL-27 levels in HT patients versus healthy controls and investigate the   A/C polymorphism’s association with genetic susceptibility to HT. Methods. Serum IL-27 was measured using ELISA, and thyroid function (FT3, FT4, TSH) was assessed. Genetic analysis identified AA, AC, and CC genotypes for the rs17855750 polymorphism to compare frequencies between study groups. Results.  IL-27 was significantly elevated in HT patients The AA genotype was significantly more frequent in the HT group  Conclusion. Findings suggest IL-27 serves as a potential biomarker, and the AA genotype contributes to HT susceptibility.