Association betweenIL39 and IL41 with Susceptibility of Systemic Lupus Erythematosus

Abstract

Cytokines are regulators of host responses to trauma, inflammation, immune responses, and infection. Aim. Study the association between IL39 and IL41 in female subjects diagnosed with Systemic Lupus Erythematosus (SLE). Methods. One hundred women with SLE, with an average age of 30.93 ± 9.85 years, were included in this study. Along with 100 healthy control women (HCW) with an average age of 32.97 ± 9.13 years, they were sourced from Baghdad city (medical city, Baghdad Hospital/Iraq). Cytokine levels were   measured   using   enzyme-linked   immunosorbent   assay   kits. Results.  According to medication, Individuals with SLE were distributed into two groups: group one (24%) of patients who were newly diagnosed (do not take any medications) and group two (76%) of patients with an illness duration (of 6.23±0.58 years who took medication. The result showed ⅠⅬ-39 values manifested a significant increase in Individuals with SLE when compared to HCW (190.3± 66.24 vs.133.5±43.53 ng/L; р < 0.0001) ROC curve analysis demonstrated that IL-39 scored 0.830 AUC (95% СI = 0.7740 - 0.8860; р < 0.0001). where IL-41 values manifested a significant decline in Individuals with SLE when compared to HCW (7.35± 0.63 vs.10.30±1.03 pg/mL; р < 0.029. ROC curve analysis demonstrated that IL-41 scored 0.693 AUC (95% СI = 0.6207 - 0.7652; р < 0.0001). Conclusion. Sera IL-39 and IL-41 concentrations were not associated with illness prevalence or severity in the current research.