Assessment the impact of zinc and copper on GST, ALP in blood of cancer patients

Abstract

Breast cancer is a highly heterogeneous disease globally. The absolute risk of breast cancer increases with age for women . Study the role of trace elements in the blood such as  (copper and zinc) and biomarkers breast cancer diagnosis such as GST, ALP . had been measured in serum of 60 women with breast disease , divided to :. the first group (A) (30) women benign breast tumors , the second group (B) (30)women breast cancer. Evaluated of serum copper and zinc of  breast cancer women was determined  by atomic absorption spectrophotometry , and the level of (GST)(Glatathione – S- transfers) enzyme  and ALP(Alkaline phosphates ) enzyme compared with control group. The results showed a significant increase ( p<0.001) in the level of enzyme (Glatathione – S- transfers) and the (Alkaline phosphates)enzyme in serum breast cancer group , while we observed a slight increase ( p<0.01) in benign tumor  group compared to the control group. However , there was a significant decrease in the level of the zinc element compared with the control group and a rise in the level of the copper element, which means  copper /zinc ratio in patients was higher than in ontrolgroup.