Effect of IL-17 Single Nucleotide Polymorphisms Gene on the Risk of Developing Colorectal Cancer in Iraqi Patients

Abstract

Interleukin -17 pathway plays an important role in development of inflammatory bowel diseases (IBD). Moreover it has been shown that this interleukin involved in anti-tumor or pro-tumor of colorectal cancer (CRC). This study determined (70) patients male to female (60% - % 40) inflicted with colorectal cancer, range aged (<16-80) years which were collected from Baghdad Teaching Hospitals/ Medical City. The patients detected for anti – IL17 by enzyme linked immune sorbent assay (ELISA) and compared with (10) individuals as a healthy control. The results showed significant differences (p<0.05). The gene encoding for the cytokine IL17 has genetically polymorphic, which has (30%) single nucleotide polymorphisms (SNPs) (12out of 40) patients by single strand conformation polymorphism technique (SSCP). In conclusion, polymorphic gene IL17 has been revealed to be associated with its susceptibility of colorectal cancer by showing there was a relationship between polymorphic gene IL17 and the occurrence of colorectal cancer as well as the clinical features of the disease especially in aged patients.