Assessments of Cytotoxic and Genotoxic Effects of Prednisolone Drug in Male Mice

Abstract

Prednisolone is a corticosteroids drug widely used for treatment of numerous conditions such as inflammation, asthma, allergies, cancer and immune diseases. The cytotoxic and mutagenic impact of this drug was evaluated in male mice by using mitotic index and sperm head abnormality assays. The study was carried out with thirty six adult male albino mice (Mus musculs).They were divided into the following groups: Treated group which orally given 0.1 mg/Kg of Prednisolone for 30days, the positive control group which take a single dose of cyclophosphamide drug (5mg/kg body weight) for 7 days other group considers as negative control received distilled water only for 30days. The drug did not induce a significant difference in the mean count of mitotic index of bone marrow and germ cells. As well as it doesn't induce a significant increase in sperm head abnormality. It can be concluded that tested dose of Prednisolone failed to induce  genotoxic and cytotoxic  impact in bone  marrow and germ cells.