Association Between Polycystic Ovary Syndrome and Genetic Polymorphisms of CYP 17 Gene in Iraqi Women

Abstract

Polycystic ovary syndrome (PCOS), whose genetic basis is not completely well understood, it is the most common endocrine disorder in women in their reproductive years.  Blood samples were collected from two groups. The first group included 61 females with PCOS and the second group included 30 normal females to detect the presence of mutation in the CYP17 gene. The two groups were genotyped and a comparison was done between them. The results showed a significant difference (p<0.05) in FSH levels in patients and normal females and there is no significant difference in the levels of Testosterone, prolactin and LH. Moreover, it showed a significant difference (p<0.05) in the levels of HDL in both patients and normal females and no significant difference in the levels of (LDL, VLDL, Triglyceride and cholesterol). Two comparisons for genotype were done: one between age and genotype and the second between BMI and genotype for each group. The results showed two types of genotype, which were a TT wild type and a heterozygote TC mutant type. Furthermore, the results showed a significant difference (p<0.05) in genotype TT and TC in the group of age less than 25 years old and no significant difference in these genotypes in age groups (25-35) and those with more than 35 years old. It is concluded from this study that this single nucleotide polymorphism in the CYP 17 gene was not associated with PCOS in Iraqi women.