Study of Chromosomal Aberrations and Micronucleus Formation in Some Iraqi Patients infected with Acute Myeloid Leukemia (AML)

  • Samara K. Mohammed , Abdul Hussein M. AL-Faisal


The effect of acute myeloid leukemia (AML) was studied on some cytogenetic parameters occur in lymphocyte in three cases; before, during and after chemotherapy treatment. The study involved 47 AML Iraqi patients their ages ranged between 2.5-81 years including 20 females and 27 males. Results were compared with 26 healthy individuals and summarized as follows: 1- AML was the most common leukemia in adults as compared with children. It was found that 46.8% AML patient ages were less than 15 years; 90.15% at 30-16 years; 40.9% at individuals at 31-45 years, the percentage increased to 90.5% in those who are over 45%. 2- AML was more common in males than females recording 57.5% and 42.5% respectively; representing 1.35:1.00 male:female ratio. 3- Two cases representing 5.3 of the studied sample exhibited dioploidy after examination under light microscope. The highest mitotic index was 7.498% and occurred in patients before taking therapy compared to 6.784% during therepy and 7.000% after therapy. 4- Micronucleus mean values recorded 0.033, 0.020 and 0.036 MN/1000 cells for AML patients before, during and after therapy respectively, when compared with the control which recorded 0.002 MN/1000cells. Nuclear division index (NDI) means before, during and after therapy of AML patients were 1.658, 1.000 and 1.424 respectively compared with control which recorded 1.282.