In silico Modeling of Beta-lactamase Protein Acinetobacter baumannii

Abstract

The most common mechanism of resistance to β-lactam antibiotics in gram-negative bacteria is the production of β-lactamases that hydrolyze the drug. Results that have been obtained from some servers that have been used in this study were gave a poor quality and prediction. SWISS MODEL server results gave more promising result as it had 92% query coverage. Validated was done for the model study by using QMEAN score, Ramachandran plot and ProSA server. 3D Refine and Mod Refiner were used for model refinement. Finally, ProSA server have been used in order to revalidate the model.