Measurement of IL-18, IFN-ᵞ Levels in Iraqi Typhoid Fever Patients

Abstract

Typhoid fever is an acute illness associated with fever caused by the Salmonella enterica serotype typhi bacteria. It can also be caused by Salmonella paratyphi, a related bacterium that usually causes a less severe illness. The aim of current study was estimated of IL-18, and IFN-ᵞ level as a diagnostic tool. The level of IL-18, and IFN-ᵞ was investigated in 254 blood specimens in patients with typhoid fever, 207(84.48%) bacterial isolates were obtained and isolated from three groups of patients, serum levels of IFN-γ and IL-18 during the chronic and acute phase in typhoid patients. The groups were determined according to clinical features and symptoms of disesase. The results have been shown higher levels in both IL-18, and IFN-ᵞ (137.187±0.703, 377.357±106.585pg/ml respectively)in chronic phase while in acute phase 128.787±2.522, 137.833±23.424pg/ml respectively) with highly significant (0.01) than those in healthy control.