The Effect of HNF1A Gene Polymorphism on Risk of Polycystic Ovary Syndrome in Sample of Iraqi Women

Abstract

Polycystic ovary syndrome (PCOS) is one of the commonest causes of female infertility. Clinical features caused by high levels of androgens, oligo menorrhea, and polycystic ovarian morphology are necessary for diagnosis. This study aims to find a relationship between the genetic polymorphism of HNF1A on the risk of Polycystic Ovary Syndrome in a Sample of Iraqi Women. The study includes one hundred subjects of Iraqi women in Baghdad (15-35 years), Patients were divided to three groups.  The first group was including Patients treated with metformin, while second group was including Patients without metformin, the third group was including apparently healthy. DNA was extracted, then the Genotyping polymorphism (rs2464196) of the HNF1A gene was done by RT-PCR. The AA genotype showed a higher frequency in the control (p=0.164) while the GG genotype showed a higher frequency in the patients (p= 0.006).