Determination of Angiotensin-Converting Enzyme 2 (ACE2) Receptor Level in Samples of Iraqi Patients Infected with COVID-19

  • Ahmed D. Almashhadani1 Amina N. AL-Thwani 2


An outbreak with signs of pneumonia that caused by (acute respiratory syndrome coronavirus 2) (SARS–CoV-2) first appear in the city of Wuhan, China, at the end of 2019, then become a global, pandemic. The Angiotensin - converting enzyme-2 (ACE2) is not considered as only an enzyme but it is also a functional receptor on the surfaces of the cells through which the SARS-CoV-2 enters the cells of the host and it is highly expressed in (heart, kidneys, and lungs). The sputum samples were collected from 84 patients and 27 healthy individuals from Baghdad Medical City and Baqubah Teaching Hospital, in period of 28 April to 1 October 2021, after collection its stored at freeze until use, then measured by Sandwich Enzyme Linked Immune Sorbent Assay. The result revealed that the levels of ACE2 receptor was elevated in patient group as compared with healthy control with high significant difference(P<0.01), the level reached to (37.20±1.796 ng/L) in COVID-19 patients, while in healthy control was (8.921±1.19 ng/L), as a conclusion Detection of ACE2 receptors in sputum of COVID – 19 patients revealed high significant difference when compared with healthy control and it is highly elevated range.