Grinding Halt Celiac Disease by Gluten Free Diet

Abstract

The aim of this study is to assess the presence of autoantibodies  in the studied groups and their significance in the detection of celiac disease (CD), and its relationship with gluten free diet (GFD).  This study included 90 subjects who  were divided  into  60 CD and 30 control groups based on the age and gender. Also, the patients group further into three groups according to period of GFD : (13) without GFD patient , (30) with GFD for period  ˂1year  and (17) with GFD for period ˃1year .  All serological tests of autoantibodies were conducted by the Enzyme linked Immunosorbent Assay (ELISA) technology. The findings revealed that all patients were seropositive for autoantibodies profile  when compared to healthy controls, with a highly significant difference (p = 0.000). Relative remission of serological tests was seen in (30) patients treated for ˂1 year, while (17) patients treated for ˃1 year showed a clear reduction in autoantibodies levels when compared to (13) patients without GFD. In conclusion, immunological tests  play an important role in the prognosis  of CD. Repeating the immunologic screen  1 year  after diagnosis and starting a GFD supports the routine measurement of using it  as a gold standard test to confirm recovery of Iraqi CD patients.