Association of Fibroblast Growth Factor-23 and Tumor Necrosis Factor-α with Autosomal Dominant Polycystic Kidney Disease in Iraqi Patients

Abstract

Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease and leads to end-stage renal disease. And it is the reason for hemodialysis in 7 to 10 percent of patients. Our study aimed to make assessment of the non-genetic factors on disease prognosis which are Tumor necrosis factor-alpha (TNF-α) and Fibroblast growth factor 23(FGF23). Blood samples were obtained from Nephrology and transplantation center/medical city and Dialysis center/lmamain Al Kadhemain Medical Teaching Hospital from ADPKD patients who have diagnosed with ADPKD according to ultrasonography diagnostic criteria and positive family history through the period from February 2021 to January 2022. The study was conducted to evaluate the serum immunological markers FGF23 and TNF-α in Iraqi ADPKD by using Enzyme Linked Immunosorbent Assay (ELISA). Result showed significant differences between ADPKD patients and apparently heathy control.