Study The Relation between the IL-6 Fold Increase in Expression and the Type of Bacteria Causing Sepsis in Burn Patients in Baghdad Governorate

Abstract

June 6, 2024 / Accepted: June 14, 2024 / Published: July 5, 2025

 Interleukin 6 (IL-6) is a well-established indicator of inflammation and is one of the first immune responses to occur in cases of sepsis. It is possible to assess serum levels quickly, typically within a few hours. The precise clinical importance of IL-6 in the initial phase of sepsis in burn individuals remains unverified. This study aimed to investigate the prognostic significance of IL-6 in burn patients with suspected sepsis, specifically in relation to bacterial infection. 44 patients with age (1.5–75 years), and 19 healthy controls with the same age range, were involved in this study during their attendance to Specialized Burns Hospital in the Medical City, Al-Kindi Teaching Hospital in Baghdad.  The study was conducted from 1st December 2023 to 1st April 2024 and approved by ethical committees of Institute of Genetic Engineering and Biotechnology for Postgraduate Studies, University of Baghdad. Blood samples and data were collected to evaluate the level of IL-6 associated with bacterial infection for burn patients by RT-qPCR System. Results appeared that mean IL-6 percentages were significantly (P≤0.01) increased in burn patients as compared with control. The current study is consistent with other research as it shows no significant differences in IL-6 levels among patients with gram-positive, gram-negative, and mixed growth.