Assocıatıon Between the Hematopoietically Expressed Homeobox ( HHEX) Gene (Rs1111875 AND Rs7923837) Polymorphısm and Type 2 Dıabetes Mellıtus in Iraqı Patıents

Abstract

This study was carried out in Baghdad Training Hospital Hereditary Research Laboratories in Baghdad, through the time from the first of March to the end of the first day of December 2022. The aim of this study is to investigate the relationship between rsllll875 and rs7923837 polymorphisms in the HHEX gene in patients with Iraqi type 2 DM. The total number of patients is 120 Iraqi individuals, including 80 patients suffering from T2DM, 40 visibly healthy samples, and the age range of these people (25-75). significant changes were noticed in high FBS level, and HbA1C level (p<0.0001). There is no significant difference in BMI. The findings found that the percentage of T2DM cases was found in the second age group, which reached 55% of the total patients, while the lowest percentage was observed in the first age group with 11.25%. The occurrence of DM was associated with family history and the effects of smoking. It was revealed that the sum of biochemical parameters Cholesterol, triglycerides, VLDL, were significant in patients, while serum HDL and LDL did not differ significantly in the control group compared to the patient group. The odds ratio C/T was more than one (rs 1111875) SNP polymorphism genotype was highly associated with the risk of developing diabetes in this studied sample.