Correlation Between NLRP3 Inflammasome Levels and Myocardial Infarction Diagnosis

Abstract

Myocardial infarction (MI) is a prevalent disease and is expected to become the main cause of death globally in the future The pathophysiology of MI is tightly linked to the activation of the NLRP3 inflammasome. This study involves 60 subjects who were enrolled in the Intensive Care Unit (ICU) at Ibn Al-Bitar Center for Cardiac Surgery. Patients admitted to the ICU at Baghdad Teaching Hospital and Ibn Al-Bitar Cardiac Surgery Center were included in this study, conducted from November 26, 2023, to November 20, 2024. The control group also consisted of 60 subjects, In this study  ,uric acid  , urea , creatinine ,Glutamic Pyruvic  Transaminase  (GPT) Glutamic Oxaloacetic  transaminase  (GOT) , Gamma Glutamyl Transferase  (GGT) ,NLPR3, NT-pro BNP  , MYL2 and LRG1 were measured .The results showed a significant increase (p≤ 0.05) in age, weight ,BMI, SBP, DBP , uric acid  , urea , Creatinine ,GPT , GOT , GGT ,TSB,NLPR3, NT-pro BNP  , MYL2 and LRG1 and a significant decrease in  height, also ,the results showed a significant   positive    correlations between NLRP3, BNP  ,MYL2 LRG1 levels   and uric acid  , urea , Creatinine, GPT , GOT , GGT ,TSB in the MI group . In conclude ROC curve analysis demonstrates that all studied parameters (NLRP3, BNP, MYL, and LEU) are highly effective in distinguishing MI group from the control group, with perfect AUC values, statistically significant results, and high sensitivity and specificity. These findings highlight their potential as reliable biomarkers for diagnosing Myocardial Infarction.