Correlation Between dyslipidemia, CA15-3 and Ki67 in diabetic Women with Breast Cancer

Abstract

Aim: To investigate the effect of dyslipidemia and the level of hyperglycemia on expression of tumor markers in diabetic women.Method: A total of 100 women patients, 66 of them had breast cancer divided in to two groups 32 diabetic women with breast cancer (G1) and 34 breast cancer women (G2) and 34 women with diabetes (G3) women in Al-Amal Tumors Center in Baghdad (3 Aug to 3 Oct) were, the level of tumor markers (Ki67, CA15-3), Age, body mass index BMI, glycosylated hemoglobin HbA1c, Cholesterol, triglyceride TG, HDL, LDL and VLDL in the two groups were determined .

Results: The level of Ki67 and CA15-3  were significantly higher in G1 and G2 compared to G3 while HbA1c were significantly higher in (G1) than (G2) at (p>0.0001) The current study also show a positive correlation between Ki67 and CA15-3 and lipid profile in G2 ,G3groups and no correlation between tumor markers and lipid profile in  (G1). Conclusion:  dyslipidemia had positive correlation with tumor markers Ki67 and CA15-3 in G1 and G2 that may contribute to high risk of breast cancer and had the main role effecting on the progression of tumor.