Association of C-Terminall Cross –Linked Telopeptide of Type Collagen with C-Reactive Protein and Rheumatoid Factor in Rheumatoid Arthritis Patients

Abstract

Rheumatoid arthritis is a chronic inflammatory disease .The condition can damage a wide variety of body systems in some people, including the skin,lungs, eyes, heart and blood vessels. The study was conducted in Al Yarmouk Teaching Hospital and Al Kadhimiya Teaching Hospital, Iraq and evaluated the biomarker of  C – Terminal Cross – Linked Telopeptides of Type II Collagen (CTX II) in 80 rheumatoid arthritis (RA) patients and 40 control men and women. Our study aimed of to investigate serum levels of CTX-II in patients with RA and possible relations with joint damage.Serum levels of CTX-II, CRP, and RF were significantly elevated in rheumatoid arthritis patients compared to control , precisely: (CTX-II : 5628.93±530.27 vs. 3382.79 ±522.89;  RF : 102.28±14.47 vs. 35.66 ±3.67 u/ml ; CRP : 10.98±2.38 vs. 4.82± 0.65 mg/L).Conclusion: serum CTX-II is a credible diagnostic biomarker that effectively distinguishes active RA patients from healthy control individuals.