Association Among HOMA-IR with Endothelin and Several Interleukins in Diabetic Mellitus Type 2 Patients

Abstract

Diabetes is the most common form of DM characterized by hyperglycemia, insulin resistance, and relative insulin deficiency.Diabetes is inflammatory disease related with several cytokines such as endothelin, IL1B,IL18, and IL37.HOMA IR is characterized as the decrease in the effectiveness of insulin in glucose utilization or over-secreting of insulin to maintain the stability of blood glucose levels related with inflammation stress .Insulin is a hormone that facilitates the transport of glucose from blood into cells, thereby reducing blood glucose (blood sugar). Insulin is released by the pancreas in response to carbohydrates consumed in the diet. In states of insulin resistance, the same amount of insulin does not have the same effect on glucose transport and blood sugar levels. Aim of this studyies to evaluate the HOMAIR level withrelation expression of Endothelin and interleukins IL1B,IL18,and IL37. The pathogenesis of diabetes is significantly influenced by interleukins. This study including more than one type of groups according toHOMA and without HOMA so the  patients divided into sub group ,and assessed the link between the gene expression of endothelin, IL1β, IL-18, and IL-37 in patients with type II diabetes. Samples were taken from type II diabetes patients and control at the Specialized Center for Endocrine Diseases and Diabetes in Baghdad between March and June 2023. For the groups under study, laboratory profiles were completed. Interluken-1β, IL-18, and IL-37 genes expression was measured by qRT-PCR.With a p-value ≤0.01, laboratory profile data revealed significant differences between patients and control in terms of HbA1c, FBS, insulin, and HOMA-IR, with out HOMA-IR. The studyresult emphasize relation aamong  between HOMA IR and cytokines in which the upregulation of endothelin and IL18 in patients with increasing HOMAIR while there downregulation in IL1B with HOMAIR.that revealed an association among study factor .