Impact of Metformin on FBXW7 Protein and Total Fatty Acids in Diabetes Individuals

Abstract

Patients with type 2 diabetes who are receiving metformin treatment should be closely monitored, particularly for progression, changes in metabolic parameters, and prediabetes. Our study aimed to evaluate FBXW7 protein levels and total fatty acids in type 2 diabetes patients receiving and not receiving metformin. One hundred volunteers participated in this study, divided into three groups: group 1: 30 untreated patients; group 2: 42 patients receiving metformin; and group 3: 28 controls. The protein FBXW7 and Total fatty acids were measured using an enzyme-linked immunosorbent assay. Lipid profiles and fasting serum glucose levels were also determined using fully automated methods for all participants. A fully automated method was also used to calculate glycated hemoglobin. After examining the effect of metformin on FBXW7 protein and total fatty acids in diabetic patients, the current study . Serum TFA levels also decreased after metformin treatment. The results demonstrate that metformin has a specific regulatory effect on FBXW7 and total fatty acids, which promotes diabetes management and fatty acid oxidation in diabetic patients. The effect of metformin on the expression of metabolic markers and FBXW7 protein in diabetic patients was significant. In conclusion, these findings highlight the importance of metformin and its effects in the diagnosis and progression of diabetes.