First edition of volume 15th of the Iraqi Journal of Biotechnology was published in the first of February 2016. This number contained eleventh research in various disciplines of genetic engineering and biotechnology. This issue contains paper with cytological, histological and physiological studies for diagnosing microbial and malignant disease. This issue also includes healing approaches using stem cells and medical plants to provide potential cure for certain diseases. Other studies are included in this issue about the molecular genetic diagnosis of various mutations and viruses and the role of stress in male infertility.