Polymorphism variation of l-selectin the pro213ser (rs2229569) in Iraqi Arab patient with type2 diabetes mellitus (T2DM)

Abstract

Type2 diabetes mellitus (T2DM) is a disorder of metabolism and complex disease affected by genetic, environmental factors, and associated with inflammation, occurs when the pancreas either doesn’t make enough insulin or the body doesn’t use the insulin as it should, lead to insulin resistance (IR) along with gradual loss of ß-cell secretory capacity . The aim of this study was to investigate the role of L-selectin gene (P213S) polymorphism in diabetes mellitus type 2 patients. Study includes seventy six Iraqi Arabs patients (male and female) having newly diagnosed type 2 diabetes mellitus (T2DM) and  fifty three Iraqi Arabs healthy subjects matched in age, sex and ethnic group. Patients and healthy subjects were genotyped, by PCR-RFLP analysis. Genotype spread analysis indicates that P213S is more frequent in the T2DM group (54.0 %), compared with the control group (16.9%). Thus our results suggest L-selectin (P213S) gene play a role in the development of DMT2 in Iraqi Arabs patients.