Study the relation of gastric cancer with helicobacter pylori infection among dyspeptic patients

Abstract

Helicobacter pylori (H. pylori) is the main causative agent of gastrointestinal diseases including chronic gastritis, peptic ulcer associated disorders, gastric and duodenal carcinomas leading to morbidity and mortality in humans. This research was conducted to study the relation of gastric cancer with H.pylori infections through some invasive methods(Histology, Direct biopsy smear, Biopsy urease test and culture methods). One hundred and twenty five dyspeptic patients were subjected to esophageal gastroduodenoscopy in Baghdad Teaching Hospital/ Endoscopy unit from10/1/2013 to 8/1/2014, gastric biopsy samples were applied for microbiological analysis.  The results showed that there was a relationship between H. pylori infection occurrence and endoscopically diagnosed Gastric cancer (3.2%); it was recorded highest H. pylori isolation (45.45%) from gastric ulcer patients followed by (25%) from gastric cancer patients. Histological examination recorded that active gastritis is found to be the most infected case (93.75%) with H. pylori followed by gastric adenocarcinoma (66.66%) gastric lymphoma (50%), so the study recorded a significant association between H .pylori infection and gastric cancer.