Rate of microRNA‑101 Level in Sample of Iraqi Patients with Chronic Hepatitis B Virus Infection

Abstract

Hepatitis B virus (HBV) Infection is highly widespread. Chronic hepatitis B infection (CHB) leads to expansion of complications, like cirrhosis, hepatocellular carcinoma (HCC) and death.  microRNAs are emerging as biomarkers for liver disease development .  this study aims to rated the level of serum  miR-101 alteration in patients with CHB and inactive carrier comparing with healthy control. A total of 67 patient’s blood samples collected during the period from February 2019 to September   2019 at Hepatology and Gastroenterology Teaching Hospital .The serum miRNA-101 expression were detected using   real time PCR. The results showed that  the serum miR-101 was downregulated in the chronic HBV and inactive carrier comparing  with the healthy subjects but there was no significant difference    (P = 0.630) was observed among them.